New test measures cancer drugs success

Cancer cellsImage copyrightScience Photo Library
Image captionThe new imaging technique measures the activity of cancer cells by detecting how well they break down pyruvate, a product of glucose

A new scanning technique is being tested to see if it gives an early indication of how well cancer drugs are working on individual patients.

The hope is that time could be saved by matching patients with the most effective treatment for their cancer.

A study of the metabolic imaging technique is taking place at the Addenbrooke’s Hospital in Cambridge.

Experts say it could lead to more personalised treatments for cancer patients.

The technique uses a product called pyruvate, which is injected into patients and tracked as it enters cells around the body.

Because it is labelled with a non-radioactive form of carbon, the molecule is very easy to detect in an MRI (magnetic resonance imaging) scan.

The scan monitors how quickly pyruvate is broken down by cancer cells – and that gives doctors an idea of how active those cells still are.

And the more active the cancer cells, the less effective the drug used to kill them.

In this way, cancer can be detected quickly and the effects of drug therapies can be monitored at an early stage, potentially saving patients time on drugs that don’t work.

The Cancer Research UK Cambridge Institute is the first place to test the technique on patients outside North America.

Dr Ferdia Gallagher, honorary consultant radiologist at the University of Cambridge, said studies on animals had shown promising results and it was time to try the technique out on humans.

“This new technique could potentially mean that doctors will find out much more quickly if a treatment is working for their patient instead of waiting to see if a tumour shrinks,” he said.

This would normally take weeks or months to discover, he said.

There could also be side-effects from the wrong treatment, which he said could be avoided, as well as money wasted on expensive cancer drugs which are not effective.

Dr Emma Smith, science information manager at Cancer Research UK, said: “The next steps for this study will be collecting and analysing the results to find out if this imaging technology provides an accurate early snapshot of how well drugs destroy tumours.”


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