Researchers came to this conclusion during the annual Global Drug Survey, which questioned more than 120,000 people in 50 countries.
Just 0.2 percent of the more than 12,000 people who reported taking the hallucinogenic drug psilocybin, which is found in the fungus, claimed that they needed emergency medical attention afterwards.
In comparison, 4.8 percent of the 1,500 people who admitted to using methamphetamine last year had to be treated — while 3.2 percent of the 1,300 synthetic cannabis users received help, the survey says.
“Magic mushrooms are one of the safest drugs in the world,” Adam Winstock, a consultant addiction psychiatrist and founder of the Global Drug Survey, told The Guardian on Wednesday.
“Death from toxicity is almost unheard of with poisoning with more dangerous fungi being a much greater risk in terms of serious harms,” he said.
While mushrooms are the safest, meth and synthetic pot — also known as K2 — are ultimately the two most dangerous drugs to use recreationally.
The second safest substance is cannabis, followed by LSD, Cocaine, Amphetamine, MDMA/Ectasy and alcohol.
“People who use psychedelics are generally very sensible and show some of the best preparation and adoption of harm reduction practices of any drug,” a summary of the survey said.